The importance of sustainable development and innovation is higher in small and medium-sized entreprises (SMEs), which cannot afford spending resources into traditional and unproductive processes. Entrepreneurship is a key driver of economy and social prosperity in Europe and we cannot afford entrepreneurs losing their motivation and competing capacity in today’s fast-moving economy. We need to make sure we equip entrepreneurs with strong foundations on the right set of skills and competencies and help them pursue innovative and sustainable means of working. This directly links to the adoption of innovative practices, taking advantage of all the tools offered in today’s digital era. Sustainability cannot be separated from a sustainable environment and this is a cycle which entrepreneurs need to appreciate and invest in: eco-innovation. This will generate a global impact on EU objectives related to the environment and climate change.